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To systematically evaluate the pathways driving this sensitivity, we performed continuous gene set enrichment analysis (GSEA) ranking all mapped genes by their Pearson correlation coefficient ( R ) between basal expression (log 2 (TPM + 1)) and the PRISM log 2 (fold de-enrichment) across the 470 matched cell lines (note that 5 cell lines were not listed on HPA and were therefore not included

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